Hormonal
The presence of metabolic syndrome significantly increases the risk of ischemic heart disease in type 2 diabetes patients, whereas individual metabolic risk factors do not significantly increase cardiovascular risk in the absence of the syndrome.
If you have Type 2 Diabetes, managing your blood pressure, cholesterol, and weight individually is not enough. You must address the cluster of metabolic issues (Metabolic Syndrome) as a whole, because the combination of these factors drastically increases your risk of heart disease, whereas treating them one by one may not reduce that risk effectively.
The existence of metabolic syndrome increased the risk of developing ischemic cardiopathy regardless of the diagnostic criteria (p< 0.05). None of the risk factors included in the metabolic syndrome was significantly associated to the occurrence of cardiovascular disease when this syndrome was non-existent.
Why this rating
Cross-sectional observational study with a large sample size (n=1005), but limited by retrospective chart review and lack of causal intervention.
Source
Type 2 diabetes and cardiovascular disease
Joshua J. Joseph et al. · Current Opinion in Endocrinology Diabetes and Obesity · 2014
DOI 10.1097/med.0000000000000044
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