Hormonal
Physical exercise restores hypothalamic insulin and leptin sensitivity in obese rodents by suppressing IKKβ and ER stress through an IL-6-dependent mechanism that requires IL-10.
If you are overweight or obese, exercise does more than just burn calories; it helps reset your brain's sensitivity to hunger and fullness hormones (insulin and leptin). This happens through a specific inflammatory pathway involving IL-6 and IL-10. This suggests that regular physical activity can help overcome the biological drive to overeat that often accompanies obesity, making it easier to maintain a healthy weight.
Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKb/NF-kB activation by a mechanism dependent upon the pro-inflammatory cytokine interleukin (IL)-6... This molecular mechanism, mediated by physical activity, involves the anti-inflammatory protein IL-10, a core inhibitor of IKKb/NF-kB signaling and ER stress.
Why this rating
High-quality mechanistic evidence using multiple genetic and pharmacological models (knockouts, antisense oligonucleotides, recombinant proteins) in rodents.
Source
IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition
Eduardo R. Ropelle et al. · PLoS Biology · 2010
DOI 10.1371/journal.pbio.1000465
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