Hormonal
High-dose vitamin D supplementation (4000-10,000 IU/day) does not improve bone health and is associated with a significant decrease in volumetric bone mineral density (BMD) at the radius and tibia compared to a low dose (400 IU/day).
If you are a healthy adult over 55 with normal vitamin D levels, taking high-dose vitamin D (4000-10,000 IU daily) will not strengthen your bones and may actually weaken them over time. Stick to standard recommended doses (around 400-800 IU) unless you have a diagnosed deficiency, as high doses can disrupt the hormones that regulate bone density.
Among healthy adults, treatment with vitamin D for 3 years at a dose of 4000 IU per day or 10 000 IU per day, compared with 400 IU per day, resulted in statistically significant lower radial BMD; tibial BMD was significantly lower only with the 10 000 IU per day dose. There were no significant differences in bone strength at either the radius or tibia.
Why this rating
Double-blind, randomized clinical trial with 311 participants, 3-year duration, and rigorous statistical analysis.
Source
Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength
Lauren A. Burt et al. · JAMA · 2019
DOI 10.1001/jama.2019.11889
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