Hormonal
Pre-operative administration of carbohydrate-rich fluids (12.5% solution, 400-800 mL) attenuates post-operative insulin resistance and endogenous glucose release, potentially reducing hospital stay and inflammatory markers in THR/TKR patients.
If you are having hip or knee replacement surgery, ask your surgical team about drinking a specific carbohydrate-rich solution (like a clear maltodextrin drink) the night before and/or 2 hours before your procedure. This is not regular food or water; it is a specific medical protocol designed to reduce surgical stress and speed up recovery. Do not do this unless your medical team approves it, as they will provide the specific type and timing.
Intake of a carbohydrate-containing fluid is reported to improve insulin-like growth factor levels, reduce hunger, nausea, and length of stay, and attenuate the decrease in whole-body insulin sensitivity and endogenous glucose release.
Why this rating
Based on a systematic review of 9 RCTs/pilot RCTs, but the authors note 'limited evidence' and 'low sample sizes'.
Source
What Is the Role of Nutritional Supplements in Support of Total Hip Replacement and Total Knee Replacement Surgeries? A Systematic Review
Louise Burgess et al. · Nutrients · 2018
DOI 10.3390/nu10070820
More from this paper
- Supplementation with Essential Amino Acids (EAA, 20g twice daily) starting one week before and continuing two weeks after Total Knee Replacement (TKR) reduces quadriceps muscle atrophy and accelerates functional mobility recovery.Moderate
- A combination of Beta-Hydroxy Beta-Methylbutyrate (HMB), L-Arginine, and L-Glutamine suppresses the loss of quadriceps muscle strength following Total Knee Replacement (TKR).Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →