Hormonal

Prior resistance exercise-induced hypertrophy creates an epigenetic memory in human skeletal muscle, evidenced by sustained DNA hypomethylation of specific genes (e.g., AXIN1, GRIK2, UBR5) during detraining, which facilitates a significantly greater hypertrophic response upon subsequent reloading compared to the initial training phase.

If you have trained before, stopped, and are starting again, your muscles may respond faster than when you first started. This is due to epigenetic changes (DNA methylation) that persist even after muscle mass returns to baseline. To leverage this, ensure your initial training phase was substantial enough to induce hypertrophy, as this creates the 'memory' that accelerates reloading gains.