Hormonal
Exogenous ghrelin infusion suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans in a dose-dependent manner.
This research indicates that higher levels of the hormone ghrelin directly reduce the body's ability to secrete insulin in response to glucose, leading to worse glucose tolerance. For healthy individuals, this suggests that conditions or interventions that significantly elevate ghrelin (like prolonged fasting or specific pharmacological agents) might impair glucose handling. It does not suggest using ghrelin as a treatment, but rather highlights it as a factor to consider in metabolic health.
This is a robust proof-of-concept study showing that exogenous ghrelin reduces glucose-stimulated insulin secretion and glucose disappearance in healthy humans.
Why this rating
Randomized, counterbalanced, controlled human trial with robust statistical analysis, though limited to healthy subjects and short duration.
Source
Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans
Jenny Tong et al. · Diabetes · 2010
DOI 10.2337/db10-0504
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →