Hormonal
Chronic low-dose aspartame consumption impairs insulin-stimulated glucose disposal and elevates fasting glucose in diet-induced obese rats, independent of changes in body composition.
Even at low doses, chronic aspartame consumption may worsen blood sugar control and insulin sensitivity, regardless of weight loss. If you are managing diabetes or insulin resistance, consider reducing or eliminating aspartame, as it may be contributing to your metabolic issues through gut microbiome changes.
aspartame elevated fasting glucose levels and an insulin tolerance test showed aspartame to impair insulin-stimulated glucose disposal in both CH and HF, independently of body composition.
Why this rating
Animal model (rats) with controlled conditions, but results may not translate directly to humans.
Source
Low-Dose Aspartame Consumption Differentially Affects Gut Microbiota-Host Metabolic Interactions in the Diet-Induced Obese Rat
Marie Palmnäs et al. · PLoS ONE · 2014
DOI 10.1371/journal.pone.0109841
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