Hormonal
Following an oral glucose load, skeletal muscle oxidation is the predominant metabolic fate of the glucose taken up by muscle, whereas glycogen storage accounts for less than 10% of the total oral load.
When you eat carbohydrates, your muscles primarily burn them for energy (oxidation) rather than storing them as glycogen. Only a small fraction (<10% of the total load) is stored in muscle. This challenges the common assumption that muscle is the main storage site for post-meal glucose.
We conclude that muscle and splanchnic tissues take up a comparable percentage of an oral glucose load and that oxidation is the predominant fate of glucose taken up by muscle, with storage in muscle accounting for < 10% of the oral load.
Why this rating
High-quality experimental design using dual isotope techniques, indirect calorimetry, and forearm balance in healthy volunteers, though extrapolated to whole-body muscle.
Source
Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load.
David E. Kelley et al. · Journal of Clinical Investigation · 1988
DOI 10.1172/jci113489
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