Macro partitioning
Replacing saturated fatty acids (SFAs) with carbohydrates does not significantly alter coronary heart disease (CHD) incidence, indicating that the specific macronutrient substitution of SFA for carbohydrate is not a primary driver of CHD risk in isolation.
Do not assume that simply swapping saturated fats for carbohydrates will lower your risk of heart disease. This study suggests that the macronutrient swap itself has no significant effect on CHD incidence. Instead, focus on the quality and source of the foods you eat.
Substituting energy from total fatty acids, SFAs, MUFAs, or PUFAs for energy from carbohydrates was not associated with CHD (Figure 2).
Why this rating
Large multi-country prospective case-cohort study (EPIC-CVD) with rigorous adjustment for confounders, though observational design limits causal inference.
Source
Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC‐CVD Case‐Cohort Study Across Nine European Countries
Marinka Steur et al. · Journal of the American Heart Association · 2021
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