Hormonal
High-protein diets (defined as >1.2 g/kg/day) cause intraglomerular hypertension and hyperfiltration, which may lead to kidney damage, proteinuria, and accelerated decline in eGFR, particularly in individuals with pre-existing chronic kidney disease (CKD) or risk factors.
If you are eating more than 1.2 grams of protein per kilogram of body weight daily, especially from animal sources, and you have any history of kidney issues, diabetes, or high blood pressure, you should monitor your kidney function (eGFR) regularly. Consider shifting some protein intake to plant sources to reduce acid load and phosphate burden, which may protect kidney health.
High dietary protein intake can cause intraglomerular hypertension, which may result in kidney hyperfiltration, glomerular injury, and proteinuria. It is possible that long-term high protein intake may lead to de novo CKD.
Why this rating
The paper is a review citing observational studies and short-term trials; long-term RCTs show mixed results, likely due to measurement limitations (creatinine) and duration.
Source
The Effects of High-Protein Diets on Kidney Health and Longevity
Gang-Jee Ko et al. · Journal of the American Society of Nephrology · 2020
DOI 10.1681/asn.2020010028
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