Hormonal
Adiponectin, des-acyl ghrelin, and leptin are adipokines that decrease insulin resistance and subsequently nonalcoholic fatty liver disease (NAFLD), whereas proinflammatory cytokines TNF-α and IL-6 enhance insulin resistance and promote NAFLD.
Your liver health is heavily influenced by hormones from your fat tissue. Maintaining a healthy weight and metabolic balance can improve levels of protective hormones like adiponectin and reduce inflammatory signals like TNF-α, thereby lowering the risk of fatty liver disease.
from analyzed data we could conclude that adiponectin, des-acyl ghrelin and leptin are adipokines that decrease, while TNF-α and IL-6 are cytokines that enhance insulin resistance and subsequently NAFLD.
Why this rating
The paper is a review summarizing multiple animal, in vitro, and human studies, but notes conflicting results and the need for larger studies.
Source
Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
Sanja Stojsavljević · World Journal of Gastroenterology · 2014
DOI 10.3748/wjg.v20.i48.18070
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