Hormonal
Prolonged TNF-α antagonism via etanercept improves fasting glucose and increases the proportion of high molecular weight (HMW) adiponectin in obese subjects with metabolic syndrome.
For obese individuals with metabolic syndrome, blocking TNF-α using etanercept can lower fasting glucose and improve the beneficial ratio of high molecular weight adiponectin. This is not a standard weight-loss treatment due to infection risks, but it may be a beneficial side effect for patients already treating autoimmune diseases like rheumatoid arthritis.
Prolonged therapy with etanercept improved fasting glucose, increased the ratio of high molecular weight to total adiponectin, and decreased sICAM-1 in obese subjects with abnormal glucose homeostasis and significant subclinical inflammation.
Why this rating
Randomized, placebo-controlled, double-blind design with a relatively long duration (6 months) and specific population (obese, metabolic syndrome).
Source
TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome
Takara L. Stanley et al. · The Journal of Clinical Endocrinology & Metabolism · 2010
DOI 10.1210/jc.2010-1170
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