Research
Hormonal
Low circulating levels of PYY are associated with obesity and reduced satiety in humans.
If you struggle with satiety, your PYY levels might be lower than average. This isn't a character flaw; it's a hormonal signal. Strategies that stimulate PYY release, such as protein-rich meals or specific surgical interventions, may help restore this natural fullness signal.
GoodSupportsHIGH confidence
low circulating PYY concentrations predispose towards the development and or maintenance of obesity. Subjects with reduced postprandial PYY release exhibit lower satiety and circulating PYY levels that correlate negatively with markers of adiposity.
Why this rating
Multiple human studies (Batterham 2003, Guo 2006, le Roux 2006) show consistent negative correlations.
Source
The role of peptide YY in appetite regulation and obesity
Efthimia Karra et al. · The Journal of Physiology · 2008
DOI 10.1113/jphysiol.2008.164269
narrative_reviewCited 318×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →