Research
Hormonal
Serotonin 2C receptors (5-HT2CRs) expressed by POMC neurons mediate the anorexigenic effects of serotonin and drugs like lorcaserin.
Drugs like lorcaserin work by targeting serotonin receptors on specific brain neurons to reduce appetite.
GoodSupportsHIGH confidence
The anorexigenic effect of serotonin is largely mediated by the serotonin 2C receptors (5-HT2CRs) expressed by the POMC neurons... Currently, d-Fen has been replaced by lorcaserin, a novel prescription diet pill and a specific agonist at 5-HT2CRs
Why this rating
Supported by pharmacological studies and receptor-specific knockout mice.
Source
Network of hypothalamic neurons that control appetite
Jong‐Woo Sohn · BMB Reports · 2015
DOI 10.5483/bmbrep.2015.48.4.272
narrative_reviewCited 317×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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