Hormonal
High-dose long-chain omega-3 supplementation (>4.4 g/day) may worsen glucose metabolism, including increasing the risk of diabetes diagnosis and raising HbA1c and fasting glucose.
If you are taking very high doses of omega-3 (more than 4.4 grams per day), be aware that this might negatively impact your blood sugar levels. While the evidence is not definitive, it suggests a potential risk of worsening glucose control at these high doses. Consult your doctor before maintaining such high doses.
A suggestion of negative outcomes was observed when dose of supplemental long chain omega-3 was above 4.4 g/d.
Why this rating
Based on fewer trials at high doses, with wide confidence intervals, suggesting a 'suggestion' rather than definitive proof.
Source
Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials
Tracey Brown et al. · BMJ · 2019
DOI 10.1136/bmj.l4697
More from this paper
- Increasing long-chain omega-3 intake has little or no effect on the risk of developing type 2 diabetes or on glucose metabolism markers (HbA1c, fasting glucose, insulin, HOMA-IR).Good
- Increasing alpha-linolenic acid (ALA) intake may increase fasting insulin levels by approximately 7%, but has little or no effect on other glucose metabolism markers.Moderate
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