Hormonal
The BclI polymorphism (G-allele) of the glucocorticoid receptor gene is associated with increased sensitivity to glucocorticoids, resulting in lower body mass index (BMI) and lean body mass in elderly populations.
If you are older and find it difficult to maintain muscle mass despite stable weight, your body may be genetically hypersensitive to cortisol. This sensitivity can lead to muscle loss (lower lean mass) rather than fat gain. Focus on resistance training to preserve lean mass, as your body may be more prone to catabolic effects from stress or endogenous cortisol.
We characterized a BclI-RFLP (restriction fragment length polymorphism) of the GR gene as a C/G polymorphism in intron 2 of which the G-allele was associated with hypersensitivity to glucocorticoids. This resulted in a lower BMI in older individuals in general, while our study in elderly males suggests that the lower BMI is probably due to a greater loss of lean mass during the ageing process.
Why this rating
Large sample sizes (up to 1963 subjects) and consistent findings across multiple tests (1mg and 0.25mg DST) and populations, though observational.
Source
Identification of the <i>Bcl</i>I polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids <i>in vivo</i> and body mass index
Elisabeth F. C. van Rossum et al. · Clinical Endocrinology · 2003
DOI 10.1046/j.1365-2265.2003.01888.x
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