Hormonal
Genetic variants in the IGF-IR and PI3KCB genes that result in lower free plasma IGF-I levels are associated with increased human longevity, specifically in individuals aged 85 and older.
This research suggests that longevity is linked to specific genetic variants that naturally keep IGF-I levels lower. There is no direct intervention protocol here, but it implies that maintaining metabolic health and avoiding excessive IGF-I elevation (e.g., through excessive caloric intake or supplementation) might align with natural longevity pathways. Focus on healthy aging rather than maximizing hormone levels.
The major finding of this investigation was that subjects carrying at least an A allele at IGF-IR have low levels of free plasma IGF-I and are more represented among long-lived people.
Why this rating
Observational cross-sectional study with a specific, carefully selected population (healthy >85yo), but lacks longitudinal follow-up and causal proof in humans.
Source
Polymorphic Variants of Insulin-Like Growth Factor I (IGF-I) Receptor and Phosphoinositide 3-Kinase Genes Affect IGF-I Plasma Levels and Human Longevity: Cues for an Evolutionarily Conserved Mechanism of Life Span Control
Massimiliano Bonafè et al. · The Journal of Clinical Endocrinology & Metabolism · 2003
DOI 10.1210/jc.2002-021810
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