Hormonal
Dietary polyunsaturated fatty acids (PUFAs) suppress hepatic glycolytic and lipogenic gene expression (specifically L-PK and FAS) by inhibiting the nuclear translocation of the transcription factor ChREBP, a mechanism independent of AMPK activation.
Consuming polyunsaturated fats (like those found in fish oil, flaxseed, or sunflower oil) alongside carbohydrates can actively suppress the liver's genetic instructions to produce new fat and break down sugar for energy. This happens because PUFAs block the 'transport' of the key regulator (ChREBP) into the cell nucleus, preventing it from turning on fat-making genes. This specific effect is not seen with saturated fats (like butter) or monounsaturated fats (like olive oil).
Our results demonstrate that the suppressive effect of PUFAs on these genes is primarily caused by an alteration of ChREBP nuclear translocation.
Why this rating
High-quality in vivo (mouse) and in vitro (hepatocyte) studies with rigorous controls (AMPK knockout mice, mutant overexpression), though not human clinical trials.
Source
Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
Renaud Dentin · Journal of Clinical Investigation · 2005
DOI 10.1172/jci25256
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