Research
Hormonal
DHEA supplementation in healthy older adults does not improve well-being, cognition, or sexual function, and its decline with age does not necessarily cause these impairments.
If you are considering DHEA supplementation for anti-aging benefits, be aware that current evidence shows it does not improve well-being, cognition, or sexual function in healthy older adults. The decline in DHEA with age does not necessarily cause these impairments, and supplementation has not been proven to reverse them.
GoodRefutesHIGH confidence
From these studies, it can be concluded that the decline in DHEA concentrations does not necessarily lead to impaired well-being, cognition or sexuality per se.
Why this rating
Based on multiple randomized placebo-controlled trials, including the largest study to date.
Source
The endocrine system and ageing
HS Chahal et al. · The Journal of Pathology · 2007
DOI 10.1002/path.2110
narrative_reviewCited 313×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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