Research
Macro partitioning
Reducing dietary protein intake (specifically BCAAs) improves insulin sensitivity in obese mice, whereas increasing BCAA intake exacerbates insulin resistance.
For obese individuals, reducing the intake of branched-chain amino acids (found in high-protein foods like meat, eggs, and dairy) may improve insulin sensitivity. Conversely, high BCAA intake can worsen insulin resistance. This suggests that the quality of protein (BCAA content) is as important as the quantity.
GoodSupportsHIGH confidence
Similar outcomes were achieved by reducing protein (and thus BCAA) intake, whereas increasing BCAA intake did the opposite; this corroborates the pathogenic roles of BCAAs and BCKAs in IR in ob/ob mice.
Why this rating
Consistent results across multiple dietary manipulation experiments in obese mouse models.
Source
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
Meiyi Zhou et al. · Diabetes · 2019
mechanism_onlyCited 311×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →