Research
Hormonal
Resistin levels are increased in obesity and induce insulin resistance by inhibiting AMPK activity and increasing SOCS3 expression.
Resistin is a hormone that increases with obesity and contributes to insulin resistance by interfering with cellular energy sensors (AMPK). Reducing obesity can lower resistin levels and improve insulin sensitivity.
GoodSupportsMEDIUM confidence
Resistin is increased in obesity, inhibits AMPK activity, increases SOCS3, and induces insulin resistance.
Why this rating
Review paper summarizing animal and some human studies.
Source
Adipokines and the Peripheral and Neural Control of Energy Balance
Rexford S. Ahima et al. · Molecular Endocrinology · 2008
DOI 10.1210/me.2007-0529
narrative_reviewCited 310×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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