Hormonal
In healthy individuals consuming low-cholesterol diets, the absolute milligram amount of dietary cholesterol absorbed (not the efficiency of absorption) is strongly and independently correlated with fasting plasma insulin, C-peptide, and glucagon levels, serving as a marker for insulin resistance.
If you are healthy and eat a balanced diet, your body's ability to absorb cholesterol (efficiency) doesn't change much based on what you eat. However, the actual amount of cholesterol you absorb is linked to higher insulin levels. To manage insulin sensitivity, focus on the total amount of cholesterol and fat in your diet rather than trying to alter your body's absorption efficiency.
The milligram amount of dietary cholesterol absorbed (but not percent absorption) was positively correlated with fasting plasma insulin (P < 0.0001), C-peptide (P = 0.0003) and glucagon (P < 0.0001) independent of gender, body fat percent and age.
Why this rating
Large sample size (n=94), rigorous dual-isotope methodology, and statistically significant independent correlations.
Source
Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry
Matthew S. Bosner et al. · Journal of Lipid Research · 1999
DOI 10.1016/s0022-2275(20)33370-8
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →