Hormonal
The ISI0,120 index of insulin sensitivity, derived from oral glucose tolerance test data, is an independent predictor of incident cardiovascular disease (CVD) risk, whereas the fasting-based HOMA-IR index is not independent of the metabolic syndrome.
If you are concerned about heart disease risk and have normal fasting glucose but other metabolic risk factors, a standard fasting insulin test (HOMA-IR) may not tell the whole story. This research suggests that how your body handles sugar after a meal (measured by ISI0,120 via an OGTT) provides independent information about cardiovascular risk that fasting tests miss. Discuss with your doctor whether an Oral Glucose Tolerance Test is warranted for comprehensive risk assessment, especially if you have family history or other metabolic syndrome components.
In conclusion, metabolic syndrome and ISI0,120 but not HOMA-IR independently predicted incident CVD.
Why this rating
Large prospective cohort (Framingham Offspring Study, n=2,898) with 7-year follow-up, though it relies on surrogate measures rather than gold-standard clamps.
Source
Insulin Resistance, the Metabolic Syndrome, and Incident Cardiovascular Events in the Framingham Offspring Study
Martin K. Rutter et al. · Diabetes · 2005
DOI 10.2337/diabetes.54.11.3252
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