Hormonal
Standard diagnostic tests (fasting glucose, HbA1c, OGTT) fail to identify glucose dysregulation in a significant subset of individuals classified as normoglycemic, who exhibit severe postprandial glucose variability and spikes into prediabetic/diabetic ranges when monitored via continuous glucose monitoring (CGM).
Standard blood tests (A1C, fasting glucose) can miss hidden glucose spikes. If you are 'normal' on labs but have risk factors, consider Continuous Glucose Monitoring (CGM) or standardized meal challenges to see how your body actually responds to food. This can reveal 'severe glucotypes' that indicate higher risk for diabetes and heart disease despite normal static labs.
We found that even individuals considered normoglycemic by standard measures exhibit high glucose variability using CGM, with glucose levels reaching prediabetic and diabetic ranges 15% and 2% of the time, respectively.
Why this rating
Observational study with CGM and standardized meals; strong internal validity for the cohort, but generalizability depends on cohort representativeness.
Source
Glucotypes reveal new patterns of glucose dysregulation
Heather Hall et al. · PLoS Biology · 2018
DOI 10.1371/journal.pbio.2005143
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