Hormonal
Gut microbiota-derived succinate acts as a signaling metabolite that regulates host energy metabolism and immune function via the SUCNR1 receptor, with effects ranging from beneficial metabolic improvements to pathological inflammation depending on context and receptor signaling integrity.
Focus on dietary fiber and diverse plant foods to support a healthy gut microbiome that produces balanced succinate levels. Avoid excessive processed foods that may cause dysbiosis. While succinate itself is not a direct supplement, its production by beneficial bacteria (like Prevotella) is linked to improved glucose metabolism.
succinate is not merely a major intermediary of the TCA traditionally considered as an extracellular danger signal in the host, but also a by-product of some bacteria and a primary cross-feeding metabolite between gut resident microbes... recent research point to some probiotic interventions directed to modulate succinate levels in the intestinal lumen, as a new microbiota-based therapies to treat obesity and related co-morbidities.
Why this rating
The paper is a review summarizing multiple studies (animal and human observational/correlational), lacking a single definitive RCT for clinical application.
Source
Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?
Sonia Fernández‐Veledo et al. · Reviews in Endocrine and Metabolic Disorders · 2019
DOI 10.1007/s11154-019-09513-z
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