Hormonal
Increased adiposity (BMI) within the normal to overweight range (non-obese) causally alters the systemic metabolite profile, adversely affecting cardiometabolic risk markers including lipoprotein subclasses, amino acids, and inflammatory markers.
If you are in your 20s or 30s and your BMI is in the overweight range (even if not obese), your body's metabolic chemistry is likely already shifting in ways that increase long-term health risks. This isn't just about weight; it's about how your body processes fats and sugars. Maintaining a healthy weight now can prevent these metabolic shifts from becoming entrenched.
Mendelian randomization indicates causal adverse effects of increased adiposity with multiple cardiometabolic risk markers across the metabolite profile in adolescents and young adults within the non-obese weight range.
Why this rating
Large sample size (n=12,664), Mendelian randomization design to establish causality, and replication across multiple cohorts.
Source
Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
Peter Würtz et al. · PLoS Medicine · 2014
DOI 10.1371/journal.pmed.1001765
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