Hormonal
A single dose of inorganic nitrate (12.9 mmol) improves exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF) by increasing peak oxygen uptake and cardiac output, without improving exercise efficiency.
If you have heart failure with preserved ejection fraction, taking a specific dose of inorganic nitrate (found in beetroot juice) before exercise can help you breathe better and move more oxygen to your muscles during intense activity. However, it does not make your body more efficient at using that oxygen, and you must avoid antibacterial mouthwash to ensure the supplement works.
NO3− supplementation significantly enhanced the reduction in systemic vascular resistance at peak exercise... This was accompanied by a significant increase in the cardiac output... Our data suggest that NO3− improves exercise capacity in HFpEF by improving the peripheral response to exercise and by providing greater O2 delivery to exercising muscles.
Why this rating
Randomized, double-blind, crossover study with 17 subjects, showing statistically significant improvements in secondary endpoints (peak VO2, cardiac output).
Source
Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction
Payman Zamani et al. · Circulation · 2014
DOI 10.1161/circulationaha.114.012957
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →