Hormonal
A higher percentage of type I skeletal muscle fibers is positively correlated with insulin-stimulated in vitro glucose transport rates in humans, whereas a lower percentage of type I fibers (associated with higher adiposity) correlates with reduced glucose transport.
Your muscle fiber composition influences how efficiently your muscles respond to insulin. A higher proportion of slow-twitch (Type I) fibers is associated with better glucose disposal. While you cannot easily change your genetic fiber type distribution, maintaining lower body fat and engaging in aerobic exercise may help optimize the metabolic function of your existing muscle fibers.
type I fiber percentage correlated with the increment in glucose transport over basal (r = 0.50, P < 0.01) but not with absolute rate. When these subjects were excluded, type I fiber percentage correlated with both the absolute transport rate (r = 0.57, P < 0.01, Fig. 4) and the increment over basal in response to insulin (r = 0.50, P < 0.01).
Why this rating
Direct human tissue measurement with rigorous statistical controls, though observational/correlational rather than interventional.
Source
Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans
Matthew S. Hickey et al. · American Journal of Physiology-Endocrinology and Metabolism · 1995
DOI 10.1152/ajpendo.1995.268.3.e453
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →