Hormonal
In obesity, chronic low-grade inflammation in brown and beige adipose tissue impairs thermogenic activity and glucose uptake, contributing to metabolic syndrome.
Obesity triggers inflammation in fat tissue that shuts down its ability to burn energy and process sugar. This isn't just about calories in vs. out; it's about the tissue's health. Reducing inflammation through healthy lifestyle choices may help restore the function of brown and beige fat, improving metabolic flexibility.
locally pro-inflammatory strong obesogenic environment in brown fat. This condition directly alters the thermogenic activity of brown fat by impairing its energy expenditure mechanism and uptake of glucose for use as a fuel substrate.
Why this rating
The paper is a review citing multiple experimental studies in rodents and humans, establishing a strong mechanistic link.
Source
Inflammation of brown/beige adipose tissues in obesity and metabolic disease
Francesc Villarroya et al. · Journal of Internal Medicine · 2018
DOI 10.1111/joim.12803
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