Hormonal
Specific polyphenols (resveratrol, curcumin, and anthocyanins) have demonstrated antidiabetic activity in human studies, whereas the therapeutic effect of individual flavonoids or isoflavones in patients is not supported by current clinical data.
If you are looking to use polyphenols for diabetes management, focus on dietary sources rich in resveratrol (grapes/wine), curcumin (turmeric), or anthocyanins (berries), as these have shown activity in human studies. Avoid relying on generic flavonoid supplements which lack therapeutic evidence in patients.
Resveratrol, curcumin, and anthocyanins showed antidiabetic activity in human study. [...] The individual flavoid or isoflavone has no therapeutic effect on diabetic patients, although the clinical data are very limited.
Why this rating
The paper explicitly states clinical data is 'very limited' for flavonoids/isoflavones, though it acknowledges activity for resveratrol, curcumin, and anthocyanins in human studies.
Source
Dietary polyphenols as antidiabetic agents: Advances and opportunities
Chongde Sun et al. · Food Frontiers · 2020
DOI 10.1002/fft2.15
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