Macro partitioning
Consumption of fructose or high-fructose corn syrup (HFCS) at 25% of energy requirements for two weeks significantly increases postprandial triglycerides, fasting LDL-cholesterol, and apolipoprotein-B in young adults, whereas glucose consumption does not produce these adverse lipid changes.
If you consume beverages providing 25% of your daily energy from added sugars, choose glucose-sweetened options over fructose or HFCS if you are concerned about post-meal triglycerides and LDL cholesterol. Two weeks of fructose or HFCS consumption significantly worsened these lipid markers in young adults, while glucose did not. Note that this applies to young, relatively lean adults; effects may differ in older or obese populations.
Consumption of HFCS-sweetened beverages for 2 wk at 25% E increased risk factors for cardiovascular disease comparably with fructose and more than glucose in young adults.
Why this rating
Randomized controlled trial with energy-balanced diets and blinded assessment, though limited to 2 weeks and young adults.
Source
Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women
Kimber L. Stanhope et al. · The Journal of Clinical Endocrinology & Metabolism · 2011
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