Hormonal
Short-term high-dose supplementation with Fructooligosaccharides (FOS) or Galactooligosaccharides (GOS) in healthy young adults causes adverse glycemic metabolism by reducing butyrate-producing bacteria.
If you are healthy, taking high doses of FOS or GOS (16g/day) for short periods might actually worsen your blood sugar response. This contradicts the common belief that prebiotics always help glucose control. The effect is linked to a drop in butyrate-producing bacteria.
Short-term intake of high-dose prebiotics had adverse effect on glucose metabolism, as in FOS intervention demonstrated by OGTT (P < 0.001), and in GOS intervention demonstrated by fasting glucose (P < 0.05).
Why this rating
Randomized double-blind cross-over study with 35 healthy adults, though short duration (14 days).
Source
Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population
Feitong Liu et al. · Scientific Reports · 2017
DOI 10.1038/s41598-017-10722-2
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →