Research
Hormonal
Reducing dietary saturated fatty acid intake leads to a stepwise increase in plasma Lipoprotein(a) [Lp(a)] concentrations.
Be aware that significantly lowering saturated fat can raise Lipoprotein(a), a specific cardiovascular risk factor. If you have high Lp(a), discuss this trade-off with your doctor when making dietary changes.
StrongQualifiesHIGH confidence
Surprisingly, plasma Lp(a) concentrations increased in a stepwise fashion as SFA was reduced. Overall, Lp(a) levels increased ~15% as saturated fat was reduced from 15% to 6% of total calories.
Why this rating
Statistically significant finding (P<.01) in a well-controlled trial.
Source
Effects of Reducing Dietary Saturated Fatty Acids on Plasma Lipids and Lipoproteins in Healthy Subjects
Henry N. Ginsberg et al. · Arteriosclerosis Thrombosis and Vascular Biology · 1998
DOI 10.1161/01.atv.18.3.441
crossover · n=103Cited 296×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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