Research
Hormonal
Industrial trans fatty acids stimulate cholesterol synthesis in the liver by activating SREBP2-mediated gene regulation, leading to increased hepatic cholesterol concentrations and steatosis.
Consuming industrial trans fats may cause your liver to overproduce cholesterol by activating specific genes (SREBP2), contributing to fatty liver and high blood cholesterol levels.
GoodSupportsHIGH confidence
In cultured hepatocytes and adipocytes, industrial trans fatty acids, but not cis-unsaturated fatty acids or SFAs, stimulate the cholesterol synthesis pathway by activating sterol regulatory element binding protein (SREBP) 2–mediated gene regulation.
Why this rating
Supported by in vitro and animal studies with consistent findings on SREBP2 activation.
Source
Mechanisms of Action of trans Fatty Acids
Antwi‐Boasiako Oteng et al. · Advances in Nutrition · 2019
DOI 10.1093/advances/nmz125
narrative_reviewCited 296×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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