Research
Hormonal
Excessive fructose intake increases plasma uric acid levels, which acts as a biomarker and potential mediator for insulin resistance and metabolic syndrome.
Be aware that high fructose intake can raise uric acid levels, which is linked to insulin resistance and metabolic syndrome. This risk is higher with sugary beverages and hypercaloric diets.
ModerateSupportsMEDIUM confidence
The rapid phosphorylation of fructose to fructose-1-phospate not only increases the fluxes of trioses for lipogenesis, but also depletes ATP stores leading to the degradation of AMP, resulting in increased generation of uric acid via purine pathway.
Why this rating
The paper notes that meta-analyses are inconsistent regarding isocaloric intake, and the clinical relevance of uric acid elevation is debated.
Source
Dietary Fructose and the Metabolic Syndrome
Marja‐Riitta Taskinen et al. · Nutrients · 2019
DOI 10.3390/nu11091987
narrative_reviewCited 295×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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