Hormonal
Young women with polycystic ovary syndrome (PCOS) exhibit significantly higher levels of high-sensitivity C-reactive protein (hsCRP) and endothelial dysfunction (reduced flow-mediated dilation) compared to healthy, age- and BMI-matched controls, independent of obesity.
If you have PCOS, your risk for early cardiovascular issues is elevated due to inflammation and blood vessel stiffness, even if you are not overweight. This risk is driven by the syndrome's hormonal and metabolic profile, not just body fat. Management should focus on addressing insulin resistance and inflammation, not just weight.
This study has shown that CRP concentrations measured using a highly sensitive assay are significantly increased in women with PCOS relative to those age and BMI-matched healthy women... The present study is the first to our knowledge to demonstrate an endothelium-dependent and endothelium-independent dysfunction in young and thin women with PCOS.
Why this rating
Randomized controlled trial design with matched controls, though observational in nature regarding the PCOS status.
Source
Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome: Relationship with Insulin Resistance and Low-Grade Chronic Inflammation
İlhan Tarkun et al. · The Journal of Clinical Endocrinology & Metabolism · 2004
DOI 10.1210/jc.2004-0751
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