Hormonal
Weight loss in obese men reduces circulating levels of IL-6 and TNF-alpha, which correlates with improved insulin sensitivity, but paradoxically increases circulating IL-8 levels.
For obese men, significant weight loss (approx 15% body weight) improves insulin sensitivity and reduces specific inflammatory cytokines (IL-6, TNF-alpha). However, be aware that IL-8 levels may paradoxically rise during this process. This rise in IL-8 does not appear to negate the metabolic benefits (insulin sensitivity) gained from the weight loss, likely due to complex release mechanisms from fat tissue or other inflammatory sources.
Plasma levels of TNF-a and IL-6 were decreased by 25– 30% ... but IL-8 was increased by 30% ... after weight loss. ... changes in IL-6 but not IL-8 were correlated with the improvement in insulin sensitivity after weight loss.
Why this rating
Randomized controlled intervention with clear statistical significance (P<0.001) and biological plausibility, though small sample size (n=19).
Source
Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men
Jens Meldgaard Bruun et al. · European Journal of Endocrinology · 2003
DOI 10.1530/eje.0.1480535
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