Research
Hormonal
Insulin resistance (IR) and hyperinsulinemia accelerate muscle protein degradation and reduce synthesis, directly causing sarcopenia.
Managing blood sugar and insulin sensitivity is crucial for preserving muscle mass. If you have insulin resistance or pre-diabetes, addressing it may help prevent the accelerated muscle loss associated with aging and metabolic syndrome.
GoodSupportsHIGH confidence
In compensatory hyperinsulinemia due to IR, glycogenesis is poorly suppressed, protein degradation is accelerated, and protein synthesis is reduced [18].
Why this rating
Supported by mechanistic studies in mice and human epidemiological data linking IR to lean body mass loss.
Source
Metabolic Syndrome and Sarcopenia
Hiroki Nishikawa et al. · Nutrients · 2021
DOI 10.3390/nu13103519
narrative_reviewCited 294×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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