Adherence
A lifestyle intervention is effective in improving cardiovascular health metrics in individuals with low baseline subclinical atherosclerosis, but ineffective in those with high baseline subclinical atherosclerosis.
If you have significant underlying cardiovascular disease (high subclinical atherosclerosis), standard lifestyle advice (diet, exercise, no smoking) may not be enough to improve your health metrics. You likely need more intensive, specialized medical or behavioral interventions. Do not assume that standard lifestyle changes will yield the same results as they do for healthier individuals.
Over the 3-year period, the intervention was effective in participants having low baseline SA [0.61 (95% CI 0.30–0.93) points] but not in those with high baseline SA [0.19 (95% CI –0.26 to 0.64) points].
Why this rating
RCT with stratified analysis, though the null result in the high SA group limits the generalizability of the 'failure' claim.
Source
Effects of a comprehensive lifestyle intervention on cardiovascular health: the TANSNIP-PESA trial
Inés García‐Lunar et al. · European Heart Journal · 2022
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