Hormonal
Metformin treatment in women with PCOS leads to regularization of the menstrual cycle, reduction in hyperandrogenism, and improvement in cardiovascular risk factors.
If you have PCOS, ask your doctor about metformin. It is the most common medication used for this condition because it helps fix the underlying insulin resistance. This can help restore regular periods, lower male hormone levels, and improve heart health risks. Lifestyle changes like diet and exercise are also recommended, especially if you are overweight.
In a high percentage of patients, treatment with metformin is followed by regularization of menstrual cycle, reduction in hyperandrogenism and in cardiovascular risk factors, and improvement in response to therapies for induction of ovulation.
Why this rating
The paper is a review citing multiple clinical trials and observational studies, though specific trial data for metformin's direct efficacy is summarized rather than detailed in the abstract.
Source
Insulin-Lowering Agents in the Management of Polycystic Ovary Syndrome
Vincenzo De Leo et al. · Endocrine Reviews · 2003
DOI 10.1210/er.2002-0015
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