Hormonal
Natural phytochemicals (resveratrol, quercetin, berberine, curcumin, fisetin) activate SIRT1, which modulates metabolic pathways, reduces oxidative stress, and exerts anti-inflammatory effects, potentially preventing or treating metabolic disorders.
Incorporate foods rich in polyphenols (berries, grapes, onions, turmeric, green tea) into your diet. While isolated high-dose supplements face bioavailability challenges, the cumulative effect of these compounds through whole foods may support SIRT1 activity, helping manage oxidative stress and inflammation associated with metabolic health.
This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin. We will also discuss the potential therapeutic effects of these natural compounds in the prevention and treatment of human disorders, with particular emphasis on their metabolic impact.
Why this rating
The paper is a review of in vitro and animal studies with limited and inconsistent human clinical trial data; bioavailability issues are a major confounder.
Source
SIRT1 Activation by Natural Phytochemicals: An Overview
Concetta Iside et al. · Frontiers in Pharmacology · 2020
DOI 10.3389/fphar.2020.01225
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