Hormonal
Acute intranasal insulin administration improves hippocampus-dependent memory and working memory in women, but not in men.
If you are a healthy woman, acute intranasal insulin may help improve your memory, but this effect does not appear to exist for men. This suggests that treatments targeting central insulin signaling for cognitive enhancement may need to account for gender-specific biological responses.
In contrast, hippocampus-dependent memory and working memory were improved in women (P < 0.03, P < 0.05, respectively), whereas men did not benefit from acute insulin treatment (P > 0.17, P > 0.20).
Why this rating
Randomized, double-blind, placebo-controlled crossover design with healthy subjects, though small sample size (n=32).
Source
Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin
Christian Benedict et al. · The Journal of Clinical Endocrinology & Metabolism · 2008
DOI 10.1210/jc.2007-2606
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →