Research
Hormonal
Regular exercise training suppresses chronic systemic inflammation by inhibiting the infiltration of inflammatory cells (neutrophils and M1 macrophages) into adipose tissue and skeletal muscle, thereby preventing tissue fibrosis and organ dysfunction associated with obesity and aging.
Engage in regular, moderate physical activity (like walking) rather than avoiding exercise due to fear of inflammation. This helps clear inflammatory cells from fat and muscle tissue, protecting your organs from age-related damage.
GoodSupportsHIGH confidence
However, these pathological changes that subsequently develop after chronic inflammation were preventable by exercise training... the applicable mechanism was identified as the suppression of neutrophil infiltration into fat tissue and the inhibition of the expression of elastase or monocyte chemoattractant protein-1 (MCP-1)
Why this rating
Supported by multiple mouse models and human observational studies cited, though the paper is a review.
Source
Chronic Inflammation as an Immunological Abnormality and Effectiveness of Exercise
Katsuhiko Suzuki · Biomolecules · 2019
DOI 10.3390/biom9060223
narrative_reviewCited 289×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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