Hormonal
Randomizing the stereospecific position of fatty acids in triacylglycerols (TAGs) alters postprandial lipid metabolism and clearance rates compared to native fats, potentially affecting cardiovascular risk factors like atherogenicity and thrombogenicity.
When choosing fats, consider that how they are processed (e.g., interesterification or randomization) can change how your body digests and clears them from your blood after a meal. While this doesn't necessarily change your fasting cholesterol numbers, it may impact your post-meal lipid response. For infants, matching the fat structure to human milk (placing palmitic acid at the sn-2 position) improves absorption and reduces calcium loss.
The positioning of unsaturated versus saturated fatty acids in the sn-2 position of TAGs indicate differences in early metabolic processing and postprandial clearance, which may explain modulatory effects on atherogenecity and thrombogenecity.
Why this rating
The paper is a review of mixed animal and human studies with inconsistent human clinical data, relying heavily on mechanistic animal models.
Source
Effects of stereospecific positioning of fatty acids in triacylglycerol structures in native and randomized fats: a review of their nutritional implications
Tilakavati Karupaiah et al. · Nutrition & Metabolism · 2007
DOI 10.1186/1743-7075-4-16
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