Research
Hormonal
Reducing brain-specific IGF-1 receptor signaling lowers somatotropic hormone output (GH/IGF-I), which extends mean lifespan and delays mortality in mammals.
This research suggests that lower levels of Growth Hormone and IGF-1 signaling are associated with a longer life in mammals. While this is a genetic study in mice, it challenges the common practice of using GH to combat aging in humans, implying that high levels of these hormones might carry a risk of shortened lifespan.
StrongSupportsHIGH confidence
Partial inactivation of IGF-1R in the embryonic brain selectively inhibited GH and IGF-I pathways after birth... led to delayed mortality and longer mean lifespan.
Why this rating
Controlled conditional mutagenesis in mice with clear phenotypic and survival data.
Source
Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism
Laurent Kappeler et al. · PLoS Biology · 2008
DOI 10.1371/journal.pbio.0060254
mechanism_only · n=138Cited 288×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →