Research
Adherence
Exercise induces WAT browning via the myokine Irisin, leading to increased energy expenditure and improved insulin sensitivity.
Regular exercise not only burns calories but also transforms white fat into beige fat, which burns energy more efficiently. This process, driven by proteins like Irisin, improves insulin sensitivity and helps manage body weight.
GoodSupportsHIGH confidence
Chronic exercise decreases body weight and fat mass by inducing browning of subcutaneous WAT. In addition, Irisin, a PGC1α-dependent myokine induced by exercise, has been shown to increase energy expenditure and to improve insulin sensitivity by activation of WAT browning.
Why this rating
Cites studies linking exercise to browning and Irisin effects, though human data on Irisin's direct role is still evolving.
Source
The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases
Jae Ho Lee et al. · International Journal of Molecular Sciences · 2019
DOI 10.3390/ijms20194924
narrative_reviewCited 287×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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