Research

Macro partitioning

Dietary carbohydrate intake drives post-prandial increases in adipose tissue lipoprotein lipase (LPL) activity via insulin secretion; high-carbohydrate, fat-free diets significantly increase LPL, whereas fat-containing diets do not.

If you eat a high-carbohydrate, low-fat meal, your body significantly increases the activity of the enzyme (LPL) that stores fat in your fat cells. Eating a fat-containing meal does not trigger this increase to the same degree. This effect is driven by the insulin response to the carbohydrates.

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In control subjects the LPL responses to feeding were not affected by obesity... the rise of both plasma insulin and adipose tissue LPL activity was dependent upon the amount of carbohydrate in the diet.
Olavi Pykälistö et al. · Journal of Clinical Investigation · 1975

Why this rating

Controlled feeding studies with direct tissue measurement.

Source

Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.

Olavi Pykälistö et al. · Journal of Clinical Investigation · 1975

mechanism_only · n=23Cited 286×
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