Research
Macro partitioning
Dietary carbohydrate intake drives post-prandial increases in adipose tissue lipoprotein lipase (LPL) activity via insulin secretion; high-carbohydrate, fat-free diets significantly increase LPL, whereas fat-containing diets do not.
If you eat a high-carbohydrate, low-fat meal, your body significantly increases the activity of the enzyme (LPL) that stores fat in your fat cells. Eating a fat-containing meal does not trigger this increase to the same degree. This effect is driven by the insulin response to the carbohydrates.
GoodSupportsHIGH confidence
In control subjects the LPL responses to feeding were not affected by obesity... the rise of both plasma insulin and adipose tissue LPL activity was dependent upon the amount of carbohydrate in the diet.
Why this rating
Controlled feeding studies with direct tissue measurement.
Source
Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.
Olavi Pykälistö et al. · Journal of Clinical Investigation · 1975
DOI 10.1172/jci108185
mechanism_only · n=23Cited 286×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Insulin is the primary regulator of human adipose tissue lipoprotein lipase (LPL) activity; insulin deficiency (as in untreated diabetes) significantly reduces LPL activity, while elevated insulin levels (as in obesity or post-prandial states) increase it.Good
- Untreated diabetic patients fail to increase adipose tissue lipoprotein lipase (LPL) activity in response to high-carbohydrate feeding due to defective insulin secretion, whereas control subjects show marked increases.Good
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