Hormonal
Roux-en-Y gastric bypass (RYGB) surgery reduces brain-hedonic responses to high-calorie foods compared to gastric banding (BAND) surgery, mediated by altered gut anatomy and increased anorexigenic hormones.
If you are considering bariatric surgery, understand that Roux-en-Y gastric bypass (RYGB) works differently than gastric banding. RYGB not only restricts food intake but also changes gut hormones (GLP-1, PYY) that reduce the brain's reward response to high-calorie foods. This neurohormonal shift may contribute to better long-term weight loss and healthier eating habits compared to gastric banding. Discuss these specific hormonal mechanisms with your surgeon to make an informed choice.
Obese patients after RYGB had lower brain-hedonic responses to food than patients after BAND surgery. RYGB patients had lower activation than BAND patients in brain reward systems, particularly to high-calorie foods, including the orbitofrontal cortex, amygdala, caudate nucleus, nucleus accumbens and hippocampus.
Why this rating
High-quality observational study with fMRI, hormonal phenotyping, and behavioral measures, though cross-sectional and non-randomized.
Source
Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding
Samantha Scholtz et al. · Gut · 2013
DOI 10.1136/gutjnl-2013-305008
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