Research
Hormonal
Adiponectin exerts neuroprotective effects by enhancing synaptic plasticity (LTP), reducing neuroinflammation, and improving insulin sensitivity, with low levels in obesity contributing to cognitive risk.
Maintaining healthy adiponectin levels through weight management and exercise is beneficial for brain health. Adiponectin helps reduce inflammation and improve insulin sensitivity in the brain, which supports memory and protects against cognitive decline.
GoodSupportsHIGH confidence
Adiponectin is known to increase insulin sensitivity... anti-inflammatory and anti-oxidant activity... adiponectin signaling directly regulates synaptic function and plasticity, preserving and enhancing cognitive functions
Why this rating
Review of multiple studies showing protective effects in animal models and some human associations.
Source
The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s Disease
Letícia Forny‐Germano et al. · Frontiers in Neuroscience · 2019
DOI 10.3389/fnins.2018.01027
narrative_reviewCited 283×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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