Hormonal
Activation of SIRT1, SIRT2, SIRT3, and SIRT6 improves insulin resistance and Type 2 Diabetes by suppressing inflammation, reducing oxidative stress, and enhancing mitochondrial function.
While specific sirtuin-activating drugs are not yet standard care, the paper suggests that lifestyle interventions mimicking calorie restriction (CR) can activate these pathways. Focus on maintaining metabolic health through balanced nutrition and physical activity to support mitochondrial function and reduce inflammation, which are the natural triggers for sirtuin activity.
These sirtuins regulate metabolism through their regulation of inflammation, oxidative stress and mitochondrial function via multiple mechanisms, resulting in the improvement of insulin resistance and T2DM.
Why this rating
The paper is a review of preclinical and mechanistic studies; it notes a lack of extensive clinical data for specific SIRT1 activators in humans.
Source
Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
Munehiro Kitada et al. · Frontiers in Endocrinology · 2019
DOI 10.3389/fendo.2019.00187
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